Expression Pattern of Id Proteins in Medulloblastoma

Id proteins in epithelial cells.

Id helix-loop-helix (Id HLH) proteins are negative regulators of basic HLH transcription factors. They are expressed during embryonic development and are important for the regulation of cell phenotypes in adults. They participate in the molecular networks controlling cell growth, differentiation, and carcinogenesis, through specific basic HLH and non-basic HLH protein interactions. Recent in vi...

ID helix-loop-helix proteins

The helix-loop-helix (HLH) family of transcription factors comprises >200 members, which have been identified in organisms from yeast to man (reviewed in Littlewood and Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrating cell cycle control, cell lineage commitment and cell differentiation. An essential role has b...

A study of the Electrophoretic Pattern of the serum Proteins

Deregulated expression of PAX5 in medulloblastoma.

Medulloblatoma is a pediatric brain tumor originating in the human cerebellum. A collection of 23 medulloblastomas was analyzed for expression of the developmental control genes of the PAX and EN gene families by RNase protection and in situ hybridization. Of all nine PAX genes investigated, only PAX5 and PAX6 were consistently expressed in most medulloblastomas (70 and 78% of all cases, respec...

Stage- and Subcellular-specific Expression of Id Proteins in Male Germ and Sertoli Cells Implicates Distinctive Regulatory Roles for Id Proteins during Meiosis, Spermatogenesis, and Sertoli Cell Function1

Immunohistological detection of each of the four Id proteins (Idl-.1d4) in sections of mouse testis revealed a unique temporal and spatial expression pattern for each Id protein during spermatogenesis. Furthermore, each Id protein displayed a distinctive, dynamic pattern of subcellular distribution. Idi was uniquely expressed in MI/MIl spermatocytes undergoing meiotic division. 1d4 protein was ...